The EORTC Gastrointestinal Tract Cancer Group: 50 years of research contributing to improved gastrointestinal cancer management

Gastrointestinal Tract Cancer

Gastrointestinal Tract Cancer, edited by Martin Lipkin and Robert Good, is a valuable addition to the medical and surgical literature. Individual chapters are contributed by distinguished scientists and clinicians who, with the editors, are to be congratulated on the clarity of presentation and consistency of literary style of the volume as a whole. Figures, tables, and graphs are illustrative ...

Cancer of the upper gastrointestinal tract.

MiR-signing gastrointestinal (con-)tract cancer

MicroRNAs (miRs) are evolutionary conserved, small non-coding RNAs with a crucial role in regulating genes expression [1]. As they target simultaneously several genes, one miR can eventually control a variety of cellular functions. Therefore, aberrations in the expression of miRs have detrimental repercussions for disease development and progression, including cancer. In the current issue, the ...

Wnt signaling, stem cells, and cancer of the gastrointestinal tract.

The Wnt signaling pathway was originally uncovered as one of the prototype developmental signaling cascades in invertebrates as well as in vertebrates. The first indication that Wnt signaling also plays a role in the adult animal came from the study of the intestine of Tcf-4 (Tcf7L2) knockout mice. The gastrointestinal epithelium continuously self-renews over the lifetime of an organism and is,...

50 Microflora of the Gastrointestinal Tract A Review